ABSTRACT
The intermediate Benzimidazo[1,2-c] quinazolin-6[5H]-thione [1] was obtained by cyclization of 2-[2'- aminophenyl] benzimidazole with carbon disulfide. Mannich base [2a-d] of compound [1] was obtained on treatment with Para formaldehyde and secondary aliphatic amines, similarly treatment of [1] with different ketones afforded respective mannich bases [3 e-h]. All derivatives synthesized were characterized from IR and 1HNMR spectral data's. Moderate anti bacterial activity was exhibited from 2a-d and from 3f, 3h against S. aureus, E. coli, and E. fecalis but very negligent activity were seen from these compounds when screened against P aeruginosa
Subject(s)
Quinazolines , Thiones , Mannich Bases , Anti-Infective AgentsABSTRACT
The frontal leaves of Tectona grandis [Verabinaceae] are widely used in the folklore for the treatment of various kinds of wounds, especially burn wound. The present study was carried out to evaluate the effect of hydrochloric extract of Tectona grandis on experimentally induced wounds in rats and compare the effects observed with a known wound healing agent, Aloe vera. The models selected were excision wound, incision wound, burn wound and dead space wound. A suitable gel formulation was selected for the application using cellophane membrane penetration. In the excision wound and burn wound models, animals treated with Tectona grandis leaf extract showed significant reduction in period of epithelisation and wound contraction 50%. In the incision wound model, a significant increase in the breaking strength was observed. Tectona grandis leaf extract treatment orally produced a significant increase in the breaking strength, dry weight and hydroxyproline content of the granulation tissue in dead space wound. It was concluded that Tectona grandis leaf extract applied topically [5% and 10% gel formulation] or administered orally [250 mg and 500 mg/kg body weight] possesses wound healing activity